Abstract: Through making the demonstrational analysis of the tax burden difference between east and west of China since the reformation of tax system, and comparing the situation of regional tax burden, economic growth and the contribution of tax, the author comes to the conclusion that the economy in east region grows faster than in the west, but the tax burden in west is higher than in the east. Moreover, the author analyzes detailedly the main factors which influent the regional tax burden difference, namely, gross economy, industrial structure, distribution of income, the design of tax system, contract system on revenue and expenditure for local governments and so on. So that the author puts forward some suggestions of perfecting the tax system, adjusting the preferential policy and promoting regional economy.