Abstract: The text considers that regional gap is a “complex” which is made up of every essential factor’s gap generally speaking. These factors includes economy, society and others which influences economic and social development. In other words, regional gap is disparity of comprehensive strength between regions. In view of above-mentioned comprehension the text puts forward a set of judging index system and quantitative measuring and calculating method which takes quantity as the dominant factor and combines quality with quantity. Furthermore, using this way the text makes quantitative calculation and omnibearing analysis to every essential factor’s gap between the east area and the west area of Shandong Province.